Rouleux formation ( arrows) :
Rouleux formation is the piling up of the erythrocytes on top of each other to resemble a stack of coins. The discoid shape of the erythrocytes helps them to perfectly stack on one another and resemble a rouleau. Physiologically seen upto slight extent in dogs, prominently seen in equines and felines. Increased numbers are in inflammatory condition leading to increased circulatory levels of fibrinogen, immunoglobulins and other acute phase reaction proteins. Increased rouleux formation is indirectly linked to the erythrocyte sedimentation rate which is increased in inflammatory conditions caused due a variety of etiologies like neoplasms, tissue damage, a cute and chronic infections and degenerative diseases.
#vetpath #vetpathology #hematology #haematology #veterinaryhaematology #dogsblood #bloodsample #wetmount #bloodundermicroscope #rouleux #rouleuxformation #rouleau #microscopy #blood
The upcoming Transfusion Medicine Workshop for Haematology Registrars in Adelaide on 23 and 24 March will provide a case-based practical review of common and important serological and clinical issues that arise in transfusion medicine practice. Find out more - learn.transfusion.com.au
Essential constituents of our blood, platelets reduce bleeding by clumping together, but their tendency to aggregate has a darker side: platelets can form dangerous blood clots, and facilitate the movement of cancerous cells in the bloodstream. Patients at high risk of blood clots are often prescribed anti-platelet medication, yet this leaves them vulnerable to severe bleeding in case of injury or surgery. Scientists are developing a solution based on modified platelets, stripped of many of their components by detergents. These platelet decoys (pictured, coloured pink) lose their ability to stick together, for example no longer becoming enmeshed in the presence of collagen fibres (in grey). Laboratory experiments suggest that treatment with these decoys reduces aggregation in the bloodstream, an effect that can rapidly be reversed by adding more real platelets. While still in early stages of testing, this quick and flexible action would represent a major improvement on existing therapies.
Written by Emmanuelle Briolat
Image from the Ingber Lab, Wyss Institute at Harvard University
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA
Image copyright held by the original authors
Research published in Science Translational Medicine, February 2019
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#science #biomedicine #haematology #hematology #Blood #bloodclot #redbloodcells #platelets
💊 Haemoglobin and Haematocrit 🧪
What Does Haemoglobin Do
i. Haemoglobin is the protein in red blood cells responsible for transporting oxygen/carbon dioxide around the body. The iron in the haem group of haemoglobin is responsible for binding oxygen. Deficiencies lead to poor oxygen transport to organs and muscle tissue, resulting in feelings of breathlessness, dizziness, cognitive impairment and exhaustion. Iron deficiency is one of the most common nutritional problems in the UK. Good sources of iron include liver/offal, red meat, spinach (remember Popeye), dark chocolate, beans/legumes and nuts. The daily recommended intake for iron in adults is 8.7 mg for men and 14.8 mg for women (aged 19-50). Side effects of excessive iron consumption have been noted above 20 mg daily intake.
ii. Calcium, phytates in cereals and legumes, and phenolic compounds found in tea, coffee and other beverages bind iron and restricts its availability for absorption, while meat and vitamin C found in fruit and vegetables enhance the potential availability of iron for mucosal uptake.
iii. Haemoglobin gives blood its red colour.
iv. Haematocrit is the measure of how much volume of blood is occupied by red blood cells.
Why Should I Test it
1. Low levels are indicative of anaemia, which can be caused by iron deficiencies, blood loss, pregnancy or liver damage.
2. High levels are suggestive of polycythaemia – abnormally high levels of red blood cells – which is confirmed by concurrent elevations in haemoglobin. This can be caused by anabolic steroid use, smoking, lung diseases (such as emphysema and COPD), living at altitude, dehydration (short term) or bone marrow disorders. (cont. in comments)
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Från en megakaryocyt beräknas
man få 2000-4000 trombocyter. From a megakaryocyte is calculated
You get 2000-4000 platelets. Trombocyters huvuduppgift är att hejda blödningar som uppstått i kroppens blodkärl genom att täppa igen de öppna sår som uppstått. Koncentrationen av trombocyter i en vuxen människas blod är 150 000-450 000 /µL Platelets'main function is to stem bleeding caused by the blood vessels of the body by closing up the open wounds incurred. Platelet concentration in a adult human blood is 150 000 - 450 000 /µ L.
#plasmacells #plasmacell #erythrocytes
#haematology #leukocytes #erytrocyter
#lymfocyter #myelocyter #monocyter
#hematologi #leukocyter #blast #blood #lymfocyt #platelet #trombocyt #megakaryocyte #megakaryocyt
hey ho, hey ho, it’s off to Uni we go!
oil on plastic
painted by me, circa “some time last century” :) .
while most students wore a sensible backpack, this bag was my trusty companion throughout 6 years of med school.
painted directly onto plastic with oil paint, my bag and I curiously survived those tough years nearly intact ...!! :)